With international classification, a requirement for diagnosis is duration of (medically) unexplained persistent or relapsing fatigue of at least six months. In practice the syndrome can be identified in cases of much shorter duration.
Features include FATIGUE which is unusual by its persistence, with:
- Poor alleviation by rest, and post-exertion malaise lasting more than 24 hours
- Impairment of life activities
- Associated muscle pain and/or joint pain without arthritis
- Recurrent sore throats
- Tender cervical or axillary lymph nodes
- Unrefreshing sleep
- Associated new or different headaches
- Cognitive impairments. These may include short-term memory and concentration difficulties and difficulty in new learning
- A large spectrum of other dysfunctions, seemingly covering almost any bodily system.